top of page

Freedom from migraine.

Delphian Therapeutics is unlocking the full therapeutic potential of endocannabinoid system modulation to treat large, poorly managed pain and neurological disorders.


Funded by the U.S. National Institutes of Health, we are leveraging the science of natural cannabinoids to develop optimized medicines for FDA and EMA approval, starting with migraine.

Screenshot 2024-12-04 143517_edited_edit

Over 1 billion people suffer from migraine.

One of the world's largest, most debilitating, most poorly managed diseases, there is a dire need for new migraine therapies.

Screenshot 2024-12-04 200006.png

Cannabinoids are one of the most exciting new areas of migraine science.

Strong evidence from dozens of multi-disciplinary studies supports the role of the endocannabinoid system, and cannabinoid efficacy, in migraine symptoms and its underlying biology.

Screenshot 2024-12-04 200207.png

Strong institutional backing.

Funded by the Migraine Research Foundation and the U.S. National Institutes of Health's National Institute on Drug Abuse (NIDA), we’ve partnered with some of the top migraine research labs in the U.S. and Europe. We operate in strict and unambiguous compliance with all national and international laws and regulations for the development of pharmaceutical products. 

Screenshot 2024-12-04 140531.png

Commitment to safety.

We strive to improve how cannabinoids are developed and used as approved medicines under national health systems around the world - optimizing health outcomes and fostering compassionate, collaborative, de-stigmatized disease management in a clinical setting. 

Partners

Screenshot 2024-12-04 132812.png
Screenshot 2024-12-04 135912_edited_edit
Screenshot 2024-12-04 132827.png

Recent News

Delphian Tx is awarded $2.9M Phase 2 SBIR from U.S. National Institutes of Health to advance to First in Human trials.

September 30, 2024

Delphian Tx Closes $2.7M Seed Round to advance development of S1-221 for migraine

May 1, 2024

Leadership

With decades of experience in pioneering cannabinoid medicines and deep experience in the migraine research, we are uniquely positioned to develop this new market.

George_Pappas_edited.jpg

George Pappas

Founder, CEO

George has over 20 years' experience in the use of cannabinoids for medical purposes. He began in patient advocacy in 2001, working with researchers and public policy leaders bringing awareness of cannabis self-medication into the public domain for the first time. He led local, state, and federal policy and regulatory initiatives, including as Field Director at Americans for Safe Access, then the nation's leading medical cannabis patient advocacy group. In 2009, he was recruited as the 1st hire at the international wing of Bedrocan BV, the sole supplier of research-quality cannabis to the Dutch Government and the world’s 1st such producer to be ISO 9000 and cGMP certified. The renowned medical program of the Dutch Health Ministry was for years the only source of cannabis for patient use in government-sponsored “special access” programs and for clinical research throughout Europe. At Bedrocan, George led projects in regulatory and market analyses, strategic planning, IP management, brand development, and more. He was involved in multidisciplinary research initiatives and in the emergence of numerous medicinal cannabis special access programs around the world. Since 2016, he has focused exclusively on developing cannabinoid medicines for FDA / EMA approval to treat large diseases to offer patients an alternative to self medication, and in 2018 he founded Schedule 1 Therapeutics.

Greg_Dussor_edited.jpg

Greg Dussor, PhD

Scientific Lead

Greg is the Chair of the Neuroscience Department at the University of Texas at Dallas. His research focuses on the mechanisms of migraine and new drug development. Greg is on the Advisory Board of the Migraine Research Foundation and associate editor of the journals Headache, PAIN, PAIN Reports, and Molecular Pain. He is also co-founder of 2 pain product companies: Ted’s Brain Science Products, an over the counter pain cream company, and CerSci Therapeutics, developing a novel FDA-approved pain treatment, which was acquired in 2020.

Terry_Ocheltree_edited.jpg

Terry Ocheltree, PhD

Regulatory VP

Terry is a former Division Director at the U.S. Food and Drug Administration. Among many other initiatives, he led the drafting of FDA’s Guidance for Industry on the Development of Botanical Drugs. Terry is a champion of and industry leader in the international harmonization of pharmaceutical manufacturing (Chemistry Manufacturing Controls, or CMC). He has held senior and VP positions at AbbVie and large regulatory consulting firms.

Alan_Rapoport_edited.jpg

Alan Rapoport, MD

Clinical Lead

Alan is Past-President of the International Headache Society, founder and Director-Emeritus of The New England Center for Headache, and co-founder of BonTriage, an app supporting migraine clinical trials and patient care. He is clinical professor of neurology at The David Geffen School of Medicine at UCLA and has extensive experience in migraine clinical trials. Board-certified in neurology and headache medicine, he has co-authored more than 350 articles, chapters, and posters on headache. Alan is an editor of Headache, CNS Drugs, and Editor-in-Chief of Neurology Reviews. He reviews for many peer-reviewed journals including Cephalalgia, Neurology, and the New England Journal of Medicine.

Selected Advisors

Gary_Winer_edited.jpg
Gary Winer

Former CEO, AbbVie Japan

Messoud_Ashina_edited.jpg
Messoud Ashina, MD, PhD

Past President, International Headache Society; Lundbeck Foundation Professor

Steve_Kuemmerle_edited.jpg
Steve Kuemmerle, PhD

Former head, Abbot Ventures

Rob_Schickel_edited.jpg
Rob Schickel, PhD

Founder and Managing Director, The CorStar Group; NUAgo Therapeutics

Steven_Wright_edited_edited.jpg
Steven Wright, MD

Former Chief Medical Officer, GW Pharmaceuticals

Paul_Burton_edited.jpg
Paul Burton, JD

Managing Partner, 2Flo Ventures

bottom of page